Moderna COVID Vaccine May Trigger Skin Reactions

By Steven Reinberg
HealthDay reporter

THURSDAY, March 4, 2021 (HealthDay News) – Some people receiving the Moderna COVID-19 vaccine may develop an injection site reaction that may first appear more than a week after receiving the vaccine, research shows.

According to researchers at Massachusetts General Hospital (MGH) in Boston, a minority of patients may experience a severe, red, sometimes increased, irritated or painful skin reaction.

Although the reaction has been seen in clinical trials, it shouldn’t discourage people from getting vaccinated against Moderna, they said.

“Whether you immediately experienced an injection site rash or that delayed skin reaction, none of these conditions should prevent you from receiving the second dose of the vaccine,” said study author Dr. Kimberly. Blumenthal. She is co-director of the clinical epidemiology program in the division of rheumatology, allergy and immunology at the MGH.

“Our immediate goal is to educate physicians and other healthcare providers about this possible delayed reaction, so that they are not alarmed, but well informed and equipped to counsel their patients accordingly,” Blumenthal said in a statement. hospital press.


Blumenthal said his own clinical group had seen and reported 12 patients with the reactions. Of these, symptoms started between four and 11 days after vaccination.

According to Dr Erica Shenoy, deputy head of the hospital’s infection control unit, this delayed skin reaction “could be mistaken – by clinicians and patients alike – for a skin infection. These types of reactions are however not infectious and therefore should not be treated with antibiotics. “

Symptoms usually go away within a week. Of the patients in the study, half had a reaction after the second stroke – at or about 48 hours after vaccination. No patient had a reaction to the second dose more severe than their reaction to the first shot, the results showed.

Dr. Esther Freeman is Director of Global Health Dermatology at the MGH. “For most of the people who go through this, we think it has to do with how the body’s immune system works,” she said. “Overall, these data are reassuring and should not discourage people from getting vaccinated.”


The results were published online on March 3 in the New England Journal of Medicine.

More information

To learn more about COVID-19 vaccines, visit the U.S. Centers for Disease Control and Prevention.

SOURCE: Massachusetts General Hospital, press release, March 3, 2021

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